Kirihito Osanai is a young doctor who's just been introduced to the Monmow disease, which transforms humans into dog-like beasts and kills them within a month of the metamorphosis. While studying the pathology of the disease Kirihito himself becomes an unknowing guinea pig for his hospital's research into it.

The world is a lonely place for Naoto and Naoya, brothers with amazing psychic powers that set them apart from humanity. Their parents cast them out–and had them imprisoned in an exploitative research center. But after they make a daring escape from the institution, Naoya has a psychic vision of an even greater threat: a deadly plague that threatens the entire world!

Brilliant doctor Kenzo Tenma risks his reputation and promising career to save the life of a critically wounded young boy. Unbeknownst to him, this child is destined for a terrible fate. Conspiracies, serial murders, and a scathing depiction of the underbelly of hospital politics are all masterfully woven together in this compelling manga thriller.